GenomicsbioRxivPreprint
Guide RNA library representation results in gene essentiality prediction bias in genome-wide CRISPR screens
Paul Metz, Sofia Alves-Vasconcelos, Richard W. R. Wallbank…·Andrew Bassim Hassan
This study shows that gRNA library representation bias affects gene essentiality predictions in CRISPR screens, with library choice being the most significant factor.
DOI 10.1101/2025.09.07.673082