Ekaterina S. Gushchanskaia

This study shows that DOT1L promotes the degradation of c-MYC and MML-1 transcription factors on chromatin, regulating their target genes and potentially offering new cancer treatment strategies.

This paper shows that DOT1L suppresses enhancer RNA transcription, preventing dsRNA formation and reducing RNAi efficiency in C. elegans.

This study shows that depletion of RdRP-produced siRNAs in C. elegans leads to ectopic elevation of noncoding RNAs and silencing chromatin marks, and suggests enhancer small RNAs guide H3K9 methylation.