Author

Benjamin C. Blum

Boston UniversityORCID 0000-0002-9525-7073Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

Andrew EmiliiD· 4 shared Weiwei LiniD· 3 shared Julian KwaniD· 2 shared Adam Thomas LabadorfiD· 1 shared Aidan F. Healy· 1 shared Ainhoa CeballosiD· 1 shared Alexandra Mora-MartiniD· 1 shared Alla GrishokiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Andrew EmiliORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

Nhat T. T. Le, Robert C.C. Mercer, Cheng Fang, Aravind Sundaravadivelu, Adam Thomas Labadorf, Weiwei Lin, Julian Kwan, Benjamin C. Blum, Andrew Emili, David A. Harris

The paper identifies prion synaptotoxic pathways and inhibitory drugs using phosphoproteomic and transcriptomic data from prion-treated neurons.

PLoS Pathogens · Jun 18, 2026Peer-reviewedNeuroscience

PANAMA enabled high sensitivity dual nanoflow LC/MS metabolomics and proteomics analysis

Weiwei Lin, Fatemeh Mousavi, Benjamin C. Blum, Christian F. Heckendorf, Matthew L. Lawton, Noah M. Lampl, Ryan Matthew Hekman, Hongbo Guo, Mark E. McComb, Andrew Emili

PANAMA enables high sensitivity joint metabolomics and proteomics analysis using nanoflow LC/MS without instrument duplication, improving resolution and detection sensitivity.

Cell Reports Methods · Jul 1, 2024Peer-reviewedSystems Biology

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin

Gian P. Sepulveda, Ekaterina S. Gushchanskaia, Alexandra Mora-Martin, Ruben Esse, Iana Nikorich, Ainhoa Ceballos, Julian Kwan, Benjamin C. Blum, Prakruti Dholiya, Andrew Emili, Valentina Perissi, Maria Dafne Cardamone, Alla Grishok

This study shows that DOT1L promotes the degradation of c-MYC and MML-1 transcription factors on chromatin, regulating their target genes and potentially offering new cancer treatment strategies.

bioRxiv · Feb 6, 2024 · PreprintMolecular Biology

A mutation in Hnrnph1 that decreases methamphetamine-induced reinforcement, reward, and dopamine release and increases synaptosomal hnRNP H and mitochondrial proteins

Qiu T. Ruan, Neema Yazdani, Benjamin C. Blum, Jacob A. Beierle, Weiwei Lin, Michal A. Coelho, Elissa K. Fultz, Aidan F. Healy, John R. Shahin, Amarpreet K. Kandola, Kimberly P. Luttik, Karen Zheng, Nathaniel J. Smith, Justin Cheung, Farzad Mortazavi, , Camron D. Bryant

This study identifies a mutation in Hnrnph1 that reduces methamphetamine-induced reinforcement, reward, and dopamine release while increasing synaptic hnRNP H and mitochondrial proteins in mice.

Journal of Neuroscience · Nov 8, 2019Peer-reviewedNeuroscience