Ruben Esse

Placental insufficiency causes fetal growth restriction in mice lacking Delta-like homologue 1

This study shows that Dlk1 is critical for placental function in mice, affecting nutrient exchange and hormone production, leading to fetal growth restriction when impaired.

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin

This study shows that DOT1L promotes the degradation of c-MYC and MML-1 transcription factors on chromatin, regulating their target genes and potentially offering new cancer treatment strategies.

ChIPdig: a comprehensive user-friendly tool for mining multi-sample ChIP-seq data

ChIPdig is a tool for analyzing multiple ChIP-seq datasets, providing read mapping, peak calling, annotation, and visualization features.

DOT1L suppresses nuclear RNAi originating from enhancer elements in Caenorhabditis elegans

This paper shows that DOT1L suppresses enhancer RNA transcription, preventing dsRNA formation and reducing RNAi efficiency in C. elegans.

The interplay between small RNA pathways shapes chromatin landscapes in C. elegans

This study shows that depletion of RdRP-produced siRNAs in C. elegans leads to ectopic elevation of noncoding RNAs and silencing chromatin marks, and suggests enhancer small RNAs guide H3K9 methylation.