Author

Gian P. Sepulveda

Boston University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

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Organism:C. elegans· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ainhoa CeballosiD· 1 shared Alexandra Mora-MartiniD· 1 shared Alla GrishokiD· 1 shared Andrew EmiliiD· 1 shared Benjamin C. BlumiD· 1 shared Ekaterina S. GushchanskaiaiD· 1 shared Iana Nikorich· 1 shared Julian KwaniD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Ainhoa CeballosORCID

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1 paper

Recent·Most cited

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin

Gian P. Sepulveda, Ekaterina S. Gushchanskaia, Alexandra Mora-Martin, Ruben Esse, Iana Nikorich, Ainhoa Ceballos, Julian Kwan, Benjamin C. Blum, Prakruti Dholiya, Andrew Emili, Valentina Perissi, Maria Dafne Cardamone, Alla Grishok

This study shows that DOT1L promotes the degradation of c-MYC and MML-1 transcription factors on chromatin, regulating their target genes and potentially offering new cancer treatment strategies.

bioRxiv · Feb 6, 2024 · PreprintMolecular Biology