Florian Neuhaus

MetaGEAR Explorer enables cross-cohort microbiome analyses to identify disease-associated microbial genes by expanding gene searches beyond sequence similarity.

The paper shows that MEIS2 and DLX5 activate enhancers for projection neurons, while LHX6 represses them in interneurons, and a MEIS2 mutation linked to intellectual disability impairs this process.

The paper investigates how progenitor competence influences GABAergic neuron maturation in mice using single-cell transcriptomics and chromatin profiling, finding that NFIB regulates maturation competence in late-born neurons.