Author

Laura Broutier

Centre de Recherche en Cancérologie de LyonORCID 0000-0001-5163-5573Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Catherine Koering· 2 shared Olivier GandrilloniD· 2 shared Alexandra BomaneiD· 1 shared Alvaro A. MartineziD· 1 shared Anda HunaiD· 1 shared Athanasios TsalikisiD· 1 shared Baptiste MouyssetiD· 1 shared Benoît DumontiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Catherine Koering

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3 papers

Recent·Most cited

Cancer BiologyPLoS Computational BiologyPeer-reviewedMar 31, 2026

Multiscale modeling of the spatial structure of stem cells in neuroblastoma patient-derived tumoroids reveals a critical role for a short-range diffusive process

Thi Nhu Thao Nguyen, Catherine Koering, Elodie Vallin…·Olivier Gandrillon

This study uses a multiscale agent-based model to show that short-range diffusive signaling among stem cells is critical for reproducing the spatial structure of neuroblastoma tumoroids.

1 citation

humanspatial transcriptomics

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Cancer BiologybioRxivPreprintJan 9, 2026

Reverse molecular pharmacology identifies the non-canonical axis of IRAK as a chemoresistance factor in neuroblastoma

Marion Le Grand, Chen Buxbaum, Mathilde Kerhervé…·Eddy Pasquier

This study identifies IRAK1 as a chemoresistance factor in neuroblastoma and shows synergy between IRAK1 inhibition and various drugs in preclinical models.

DOI 10.64898/2026.01.09.697473

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintAug 28, 2024

MYC shapes ER-mitochondria calcium transfer by directly targeting ITPR1: implications for MYC-induced safeguard mechanisms and cancer

Xingjie Ma, Athanasios Tsalikis, Mathieu Vernier…·David Bernard

This study shows MYC regulates ITPR1 to control ER-mitochondria calcium transfer, inducing cell death in normal cells but exploited by cancer cells for survival.

1 citation

humanexperimental assay

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