Nicholas O’Toole

This study shows insulin signaling links prenatal adversity to long-term brain and behavioral changes, with sex-specific effects in rats.

The paper identifies a glucocorticoid-responsive gene network in the anterior cingulate cortex that moderates the link between early-life adversity and depression risk in adult females.

This study investigates how prenatal maternal immune activation and adolescent circadian disruption interact to affect neurodevelopmental outcomes in mice, showing sex-specific behavioral and molecular effects.

This study identifies expression networks of MDD risk genes linked to astrocyte fatty acid metabolism and suicidal ideation, suggesting PPARA as a therapeutic target.

The paper defines a homeostatic inflammation signature in the placenta, creates a polygenic score, and shows its protective effects on cardiovascular and depressive outcomes using UK Biobank data.

The paper identifies convergent genomic modules in stress models of mice, revealing shared biological functions across different stress paradigms.

The paper identifies epigenetic changes in mice exposed to chronic social defeat stress, showing convergence with human neuroticism pathways.

The paper investigates how environmental enrichment affects brain volume in mice and identifies molecular processes involved, showing CREB is not required for these changes.