Author

Xianglan Wen

Douglas Mental Health University Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Neuroscience· 3 Genomics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:rat· 1

Frequent Co-Authors

Nicholas O’TooleiD· 4 shared Tieyuan ZhangiD· 4 shared Carine I. ParentiD· 2 shared Josie C. Diorio· 2 shared Michael Joseph MeaneyiD· 2 shared Patrícia Pelufo SilveiraiD· 2 shared Aashita BatraiD· 1 shared Alexander von Friesen· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersNeuroscience

Nicholas O’TooleORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Insulin modulates mPFC gene expression and emotional behavior in a sex-specific manner following fetal growth restriction

Patrícia Maidana Miguel, Bárbara Barth, Aashita Batra, Márcio Bonesso Alves, Danusa Mar Arcego, Bonnie Alberry, Roberta Dalle Molle, Ameyalli Gómez‐Ilescas, Tieyuan Zhang, Xianglan Wen, Carine I. Parent, Nicholas O’Toole, André Krumel Portella, Patrícia Pelufo Silveira

This study shows insulin signaling links prenatal adversity to long-term brain and behavioral changes, with sex-specific effects in rats.

Brain Behavior and Immunity · Jun 30, 2026Peer-reviewedGenomics

Genomic Modules and Intramodular Network Convergency of Susceptibility and Resilience in Multimodeled Stress in Male Mice

Jordan Marrocco, Salvatore G. Caradonna, Tieyuan Zhang, Nicholas O’Toole, Mojun Shen, Huzefa Khalil, Nathan R. Einhorn, Xianglan Wen, Carine I. Parent, Francis S. Lee, Huda Akil, Bruce S. McEwen, Michael Joseph Meaney

The paper identifies convergent genomic modules in stress models of mice, revealing shared biological functions across different stress paradigms.

bioRxiv · Jun 30, 2021 · PreprintNeuroscience

Epigenetic signatures of chronic social stress in stress-susceptible animals

Nicholas O’Toole, Tieyuan Zhang, Xianglan Wen, Josie C. Diorio, Patrícia Pelufo Silveira, Benoît Labonté, Eric J. Nestler, Michael Joseph Meaney

The paper identifies epigenetic changes in mice exposed to chronic social defeat stress, showing convergence with human neuroticism pathways.

bioRxiv · Jul 3, 2019 · PreprintNeuroscience

Genetic and behavioural requirements for structural brain plasticity

Dulcie A. Vousden, Alexander von Friesen, Xianglan Wen, Lily R. Qiu, Nicholas O’Toole, Benjamin C Darwin, Leigh Spencer Noakes, Rylan Allemang-Grand, Josie C. Diorio, Paul W. Frankland, Sheena A. Josselyn, Brian J. Nieman, Michael J. Meaney, Tieyuan Zhang, Jason P. Lerch

The paper investigates how environmental enrichment affects brain volume in mice and identifies molecular processes involved, showing CREB is not required for these changes.

bioRxiv · Oct 3, 2018 · PreprintNeuroscience