Author

Christine Beeton

Baylor College of MedicineORCID 0000-0002-2500-5874Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:rat· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Joseph M. HyseriD· 2 shared Adam B. Castoreno· 1 shared Alexandria M. DoerfleriD· 1 shared Ayrea E. HurleyiD· 1 shared Brinkley A. MorseiD· 1 shared Christopher J. WalkeyiD· 1 shared Duolong ZhuiD· 1 shared Frank T. HorriganiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Joseph M. HyserORCID

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3 papers

Recent·Most cited

The L-type voltage-gated Ca2+ channel CaV1.2 regulates fibroblast-like synoviocytes invasiveness during rheumatoid arthritis

Mark R. Tanner, R. Nicholas Elston, Madilyn J Brandt, Brinkley A. Morse, Liang Tso Sun, Shengwei Zou, Joseph M. Hyser, Frank T. Horrigan, Teresina Laragione, Pércío S. Gulko, Christine Beeton

This study identifies CaV1.2 as a Ca2+ influx channel that interacts with KCa1.1 to regulate invasiveness of RA-FLS through Ca2+ homeostasis.

bioRxiv · Oct 14, 2026 · PreprintCell Biology

In vivo expansion of gene-targeted hepatocytes through transient inhibition of an essential gene

Marco De Giorgi, So Hyun Park, Adam B. Castoreno, Mingming Cao, Ayrea E. Hurley, Lavanya Saxena, Marcel A. Chuecos, Christopher J. Walkey, Alexandria M. Doerfler, Mia N. Furgurson, M. Cecilia Ljungberg, Kalyani R. Patel, Sarah Hyde, Tyler Chickering, Stephanie Lefebvre, , William R. Lagor

This paper introduces a method to increase the proportion of correctly repaired hepatocytes in the liver through transient gene inhibition and transgene delivery, achieving a 25% increase in targeted cells and five-fold transgene expression.

Science Translational Medicine · Feb 12, 2025Peer-reviewedGenetics

A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis

Yuqing Wang, Duolong Zhu, Laura Ortiz-Velez, Jacob L. Perry, Michael W. Pennington, Joseph M. Hyser, Robert A. Britton, Christine Beeton

This paper develops a bioengineered probiotic to deliver a Kv1.3 channel blocker peptide for treating rheumatoid arthritis, showing efficacy in reducing inflammation and joint damage in rat models.

Proceedings of the National Academy of Sciences · Jan 3, 2023Peer-reviewedSynthetic Biology