Author
Technische Universität DarmstadtORCID 0000-0001-5258-1255Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Robert Knieß, W.‐Matthias Leeder, Paul Reißig…·H. Ulrich Göringer
The paper describes DNA-cholesterol nanoparticles that kill Trypanosoma brucei by disrupting lysosomal membrane integrity and demonstrate a dual-target approach using DNAzymes.
W.‐Matthias Leeder, Felix Klaus Geyer, H. Ulrich Göringer
The paper identifies a fuzzy RNA-recognition mechanism by the Trypanosoma brucei editosome using graph-based analysis of RNA motifs.
Cristian Del Campo, W.‐Matthias Leeder, Paul Reißig, H. Ulrich Göringer
The paper develops an improved in vitro assay to monitor editosome function in trypanosomes using high-throughput capillary electrophoresis and fluorophore-labeled substrates.
W.‐Matthias Leeder, Fabian Giehler, Juliane Joswig, H. Ulrich Göringer
The paper designs synthetic trypanolytic factors (synTLF) inspired by natural TLF complexes, demonstrating their ability to kill African trypanosomes through lysosomal lysis.
Christin Voigt, Mateusz Dobrychłop, Elisabeth M. Kruse…·H. Ulrich Göringer
The paper investigates RNA-chaperone activity of OB-fold proteins in the Trypanosoma brucei editosome, showing activity differences correlate with surface areas and intrinsically disordered subdomains.
W.‐Matthias Leeder, Stephan Voskuhl, H. Ulrich Göringer
The paper investigates how macromolecular crowding affects the 2D-structure of the T. brucei pre-edited RPS12 mRNA and finds no significant impact.