H. Ulrich Göringer

Nanopore-based direct RNA sequencing of the Trypanosoma brucei transcriptome identifies novel lncRNAs

This study uses long-read direct RNA sequencing to identify 207 novel lncRNAs in T. brucei, including stage-specific ones, providing a comprehensive view of its transcriptome.

Core-shell DNA-cholesterol nanoparticles exert lysosomolytic activity in African trypanosomes

The paper describes DNA-cholesterol nanoparticles that kill Trypanosoma brucei by disrupting lysosomal membrane integrity and demonstrate a dual-target approach using DNAzymes.

Fuzzy RNA-recognition by the Trypanosoma brucei editosome

The paper identifies a fuzzy RNA-recognition mechanism by the Trypanosoma brucei editosome using graph-based analysis of RNA motifs.

Analyzing editosome function in high-throughput

The paper develops an improved in vitro assay to monitor editosome function in trypanosomes using high-throughput capillary electrophoresis and fluorophore-labeled substrates.

Cell-free prototyping of AND-logic gates based on heterogeneous RNA activators

This study designs AND-logic gates using RNA components and tests them in vitro and in vivo, showing comparable performance to protein circuits.

Bioinspired Design of Lysolytic Triterpenoid-Peptide Conjugates that Kill African Trypanosomes

The paper designs synthetic trypanolytic factors (synTLF) inspired by natural TLF complexes, demonstrating their ability to kill African trypanosomes through lysosomal lysis.

Surface-driven RNA-refolding by the OB-fold proteins of the Trypanosoma brucei editosome

The paper investigates RNA-chaperone activity of OB-fold proteins in the Trypanosoma brucei editosome, showing activity differences correlate with surface areas and intrinsically disordered subdomains.

The 2D-structure of the T. brucei pre-edited RPS12 mRNA is not affected by macromolecular crowding

The paper investigates how macromolecular crowding affects the 2D-structure of the T. brucei pre-edited RPS12 mRNA and finds no significant impact.