Samantha Mar

This study compares functional, transcriptomic, and proteomic profiles of human primary and stem cell-derived beta cells in high and low insulin production states, revealing differences in resilience and protein machinery.

The paper identifies fibroblast growth factors (FGFs) as protective for human stem cell-derived insulin-secreting beta cells through a medium-throughput screen.

The paper develops a dual fluorescent reporter hESC line to track insulin- and glucagon-expressing cells during differentiation, revealing bihormonal cells preferentially become alpha-like.