Ana Petelinec

This study compares mitosis in 3D tumor spheroids and 2D monolayers, finding prometaphase delays and proteomic changes in spheroids.

The paper identifies a universal scaling law for mitotic spindles across eukaryotes, showing metaphase plate width scales with genome size following a power law with an exponent of ~1/3, driven by chromosome crowding.

This study shows that reducing microtubule poleward flux can rescue chromosome segregation errors in cancer cells by slowing kinetochore microtubule growth and improving alignment.