Kruno Vukušić

Mitotic adaptations shape acquired resistance and vulnerabilities to KIF18A inhibition in cancer

This study identifies resistance mechanisms and vulnerabilities to KIF18A inhibition in cancer cells using CRISPR screening and drug adaptation.

The SKA complex is a mitotic vulnerability of chromosomally unstable cancers

The paper identifies the SKA complex as a mitotic vulnerability in chromosomally unstable cancers, showing its selective impact on these cells through prolonged mitosis.

Mitotic errors drive rapid clearance of polyploidy during intestinal regeneration despite robust centrosome clustering

The paper shows that polyploid cells in intestinal regeneration are cleared through mitotic errors despite centrosome clustering, leading to rapid loss of faulty lineages.

Polar chromosomes are rescued from missegregation by spindle elongation-driven microtubule pivoting

The paper shows that spindle elongation rescues polar chromosomes from missegregation by pivoting astral microtubules toward the spindle surface, with implications for chromosomal instability in cancer.

Mitotic BLM functions are required to maintain genomic stability

This study shows that BLM helicase is essential for resolving ultrafine DNA bridges during mitosis, preventing genomic instability.

Kinetochore-centrosome feedback linking CENP-E and Aurora kinases controls chromosome congression

The paper shows Aurora A and CENP-E interact via a feedback loop to control chromosome congression by modulating kinetochore-microtubule attachments and spatial cues.

A universal scaling law for mitotic spindles across eukaryotes driven by chromosome crowding

The paper identifies a universal scaling law for mitotic spindles across eukaryotes, showing metaphase plate width scales with genome size following a power law with an exponent of ~1/3, driven by chromosome crowding.

Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy

The study identifies genetic determinants of reproductive aging linked to egg aneuploidy by analyzing maternal exomes and shows kinesin gene variants contribute to aneuploidy and accelerated aging.