Iva M. Tolić

This study identifies resistance mechanisms and vulnerabilities to KIF18A inhibition in cancer cells using CRISPR screening and drug adaptation.

The paper identifies the SKA complex as a mitotic vulnerability in chromosomally unstable cancers, showing its selective impact on these cells through prolonged mitosis.

The paper shows that polyploid cells in intestinal regeneration are cleared through mitotic errors despite centrosome clustering, leading to rapid loss of faulty lineages.

The paper shows that spindle elongation rescues polar chromosomes from missegregation by pivoting astral microtubules toward the spindle surface, with implications for chromosomal instability in cancer.

This study compares mitosis in 3D tumor spheroids and 2D monolayers, finding prometaphase delays and proteomic changes in spheroids.

This study shows that BLM helicase is essential for resolving ultrafine DNA bridges during mitosis, preventing genomic instability.

This study resolves a paradox in spindle length control by showing that coordinated regulation at both microtubule ends allows spindle length and poleward flux to vary independently.

The paper shows Aurora A and CENP-E interact via a feedback loop to control chromosome congression by modulating kinetochore-microtubule attachments and spatial cues.

The paper identifies a universal scaling law for mitotic spindles across eukaryotes, showing metaphase plate width scales with genome size following a power law with an exponent of ~1/3, driven by chromosome crowding.

This study shows that reducing microtubule poleward flux can rescue chromosome segregation errors in cancer cells by slowing kinetochore microtubule growth and improving alignment.

The study identifies genetic determinants of reproductive aging linked to egg aneuploidy by analyzing maternal exomes and shows kinesin gene variants contribute to aneuploidy and accelerated aging.