Cornelis A. M. de Haan

Infection drives localised and individualised antibody repertoires, whereas immunisation promotes repertoire convergence in pig

This study compares antibody repertoires in pigs after infection and immunisation, finding infection drives compartmentalised, individualised responses while immunisation promotes convergent, public repertoires.

Spike and host glycan determinants of HKU1 airway tropism

This study identifies spike and host glycan determinants of HKU1 airway tropism by showing preferential binding to 9-O-acetylated 2,8-linked disialosides and structural insights into ligand recognition.

The gH/gL/gO Complex of Elephant Endotheliotropic Herpesvirus 1A Functions as a Receptor Binding Complex

This paper determines the structure of the EEHV1A gH/gL/gO complex and shows it functions as the receptor-binding complex for EEHV1A.

Structural basis for postfusion-specific binding to Respiratory Syncytial Virus F protein by the canonical antigenic site I antibody 131-2a

This study determines the epitope of the postfusion-specific antibody 131-2a against RSV-F using mass spectrometry, revealing the structural basis for its specificity.

A Spike Trimer Dimer-Inducing Nanobody with Anti-Sarbecovirus Activity

This paper describes a nanobody, 7F, that neutralizes SARS-CoV-2 and cross-neutralizes SARS-CoV and SARS-like CoV pseudoviruses by inducing spike trimer dimers and shows therapeutic potential in 3D tissue cultures.

Fc-dependent protective efficacy of non-inhibitory antibodies targeting influenza A virus neuraminidase is limited by epitope availability

This study identifies Fc-dependent protective antibodies against influenza A virus neuraminidase, showing that epitope availability and Fc-mediated effector functions influence their efficacy.