Alexander F. Gileta

RatXcan: A framework for cross-species integration of genome-wide association and gene expression data

RatXcan extends transcriptome-wide association studies to rats, enabling cross-species integration of GWAS and gene expression data to identify shared genetic mechanisms of complex traits.

Exponential increase in QTL detection with increased sample size.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies

The paper genotypes over 4,000 Sprague Dawley rats to characterize genetic diversity and performs GWAS on Pavlovian conditioned approach behavior, identifying 46 significant loci.

Genome wide association study in 3,173 outbred rats identifies multiple loci for body weight, adiposity, and fasting glucose

Adapting genotyping-by-sequencing and variant calling for heterogeneous stock rats

The paper adapts genotype-by-sequencing for HS rats to call and impute over 3.7 million SNPs with 99% concordance compared to a genotyping array.