Silvia Velasco

This paper benchmarks spatial transcriptomics in stem cell-derived organoids using Stereo-seq, optimizing RNA capture and introducing regional analysis methods.

FLAMESv2 is a flexible R/Bioconductor package for analyzing long-read single-cell RNA-seq data, demonstrating field-leading performance in isoform analysis and cell-type identification.

The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.

The paper presents a single-cell multiomics atlas of human cortical organoid development, revealing molecular programs of cellular diversification and identifying human-specific gene roles in lineage establishment.

This study uses human brain organoids to show that ASD risk genes cause accelerated development of specific cortical neuron classes.

The paper introduces SeqUnwinder, a method to identify sequence features specific to overlapping regulatory annotations, demonstrating its application on TF binding and chromatin state data.

The paper identifies galectin-4 as a neuronal factor that establishes and regulates non-myelinated axon segments by forming membrane domains that exclude myelination.