Paola Arlotta

The paper compares microglia-targeted AAVs, finding that capsid choice affects in vitro efficiency but not in vivo transduction when using specific promoters.

The paper identifies a reversible apoptotic checkpoint in aging mouse hippocampal neuroblasts that limits neurogenesis and can be mitigated by voluntary running.

The paper identifies age-related changes in cortical astrocytes, including impaired Wnt signaling and Jun transcription factors, using single-cell RNA-seq and multiome analysis in mice.

This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.

This study uses snRNA-seq to track the transcriptional changes in adult hippocampal neurons from birth to maturity, identifying key transcription factors and molecular switches involved in their differentiation.

This study shows that microglia mediate fetal brain transcriptional responses to maternal inflammation, highlighting their role in neurodevelopmental outcomes.

The paper identifies neuron-class specific signals that drive differential myelination across cortical layers using single-cell data from mouse neocortex.

The paper introduces a multi-donor brain organoid model called Chimeroids to study individual genetic variation in neurotoxin susceptibility.

The paper investigates how PTEN heterozygous mutations affect different cell types in human cortical organoids and shows that these effects lead to abnormal circuit activity regardless of genetic background.

The paper presents a single-cell multiomics atlas of human cortical organoid development, revealing molecular programs of cellular diversification and identifying human-specific gene roles in lineage establishment.

The paper identifies human-specific enrichment of schizophrenia risk genes in callosal neurons of the developing neocortex using comparative transcriptomic analysis across species and developmental stages.

This study uses in vivo Perturb-Seq to analyze the effects of 35 autism risk genes on neuronal and glial cells in the developing brain.

This study uses human brain organoids to show that ASD risk genes cause accelerated development of specific cortical neuron classes.

This study identifies temporally divergent regulatory mechanisms in neuronal development and maturation across mouse and marmoset neocortex.

The paper investigates how different neuron types in the mouse visual cortex adapt myelination in response to sensory experience, finding that only inhibitory interneurons undergo experience-dependent myelin remodeling.

The paper generates a single-cell RNA-seq and ATAC-seq atlas of the developing mouse neocortex and reconstructs developmental trajectories to infer gene regulatory programs and identify lineage-specific developmental abnormalities.

The paper develops genetic tools to dissect glutamatergic neuron subpopulations and their developmental trajectories in the cerebral cortex.

The paper improves Slide-seq technology to enhance mRNA capture sensitivity, enabling high-resolution spatial transcriptomics in mouse tissues.

FIN-Seq enables transcriptional profiling of specific cell types in frozen human CNS tissues using immunolabeled nuclei sequencing.

The paper develops all-optical electrophysiology tools to record subthreshold dynamics and excitability in mouse hippocampus during behavior, revealing brain-state dependent changes in neuronal activity.