ImmunologybioRxivPreprint
PD-1 blockade enhances T cell activation by reorchestrating CD28 and CTLA4 ligand interactions
Gee Sung Eun, Jonathan Boyd, Vinh Au…·Rajat Varma
This study shows PD-1 blockade enhances T cell activation by altering ligand interactions between CD28, CTLA4, and PD-1, leading to stronger CD28-CD80 co-stimulation.
DOI 10.64898/2026.04.12.718055