Alison F. Munro

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

This study screens a large compound library across patient-derived GBM stem cells to identify effective drugs targeting tumor heterogeneity and presents validated hits for further exploration.

This study identifies a synergistic combination of FAK and MEK inhibitors that effectively targets glioblastoma heterogeneity and improves therapeutic outcomes.

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

The paper identifies a cytoplasmic structure, SIP, that mediates non-genetic control of cell plasticity and phenotypic states through lncRNAs and signaling pathways.

The paper identifies two distinct neuroinflammatory signatures in ALS cohorts using gene expression analysis and validates their association with clinical metrics.