Costanza Borrelli

APOA1 links a late fetal epithelial program to colonic maturation and injury responses

This study identifies APOA1 as a marker of a late fetal colonic epithelial state that reappears after injury, linking it to colonic maturation and injury responses through interactions with WNT5A and regulation by HOXB7.

Identifying Spatial Co-occurrence in Healthy and InflAmed tissues (ISCHIA)

ISCHIA identifies spatial co-occurrence patterns in healthy and inflamed human tissues using spatial transcriptomics data.

Sphere-sequencing unveils local tissue microenvironments at single cell resolution

Sphere-sequencing identifies zonated genes and ligand-receptor interactions in mouse metastatic liver microenvironments at single cell resolution.

TBX3 acts as tissue-specific component of the Wnt/β-catenin enhanceosome

The paper identifies TBX3 as a tissue-specific component of the Wnt/β-catenin enhanceosome, showing its role in transcriptional regulation and metastasis in colorectal cancer.