Shlomit Edri

This paper generates pancreatic aggregates from mouse stem cells with mesoderm and pancreatic progenitors, showing increased endocrine cell production compared to controls.

The paper develops a 3D atlas of the embryonic pancreas to analyze cell interactions and spatial organization in mouse embryos.

The paper analyzes in vitro NMPs derived from ESCs and EpiSCs, finding that EpiSC-derived NMPs more closely resemble in vivo NMPs and contain a node-like population maintaining T expression.

The paper identifies a multipotent progenitor population derived from Epiblast Stem Cells that self-renew and express a gene signature similar to embryonic NMPs.

The paper shows that inhibiting Kat2a increases transcriptional heterogeneity in mouse embryonic stem cells, leading to reduced pluripotency and accelerated differentiation.