Molecular BiologybioRxivPreprint
Trans-branching of polyubiquitin chains orchestrates the DNA replication stress response
Kirill S. Petriukov, Christian Renz, Markus S Schraft…·Helle D. Ulrich
The paper shows that branching of polyubiquitin chains on PCNA, mediated by UBE2K, orchestrates the DNA replication stress response by promoting re-priming of stalled forks and requiring BRCA1-dependent repair.
DOI 10.64898/2026.09.01.748521