Trans-branching of polyubiquitin chains orchestrates the DNA replication stress response
Kirill S. Petriukov, Christian Renz, Markus S Schraft, Ivan Mikičić, Nils Christian Krapoth, Abhik Thapa, Petra Beli, Helle D. Ulrich
The paper shows that branching of polyubiquitin chains on PCNA, mediated by UBE2K, orchestrates the DNA replication stress response by promoting re-priming of stalled forks and requiring BRCA1-dependent repair.
bioRxiv · Sep 3, 2026 · PreprintMolecular Biology