Manon Chadourne

circPMS1-mediated LIM protein scaffolding promotes cytoskeletal remodeling and melanoma metastasis

This study identifies circPMS1 as a pro-metastatic circRNA in melanoma that promotes cytoskeletal remodeling and metastasis by scaffolding LIM proteins.

The small MAF transcription factor MAFG co-opts MITF to promote melanoma progression

This study identifies MAFG as a driver of melanoma progression by interacting with MITF to alter gene expression and promote a dedifferentiated melanoma phenotype.

FRA1 drives melanoma metastasis through an actionable transcriptional network

This study identifies FRA1 as a driver of melanoma metastasis and shows that targeting its downstream genes AXL, CDK6, and FSCN1 suppresses metastasis and improves survival.

CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma

Topaz1, an essential gene for murine spermatogenesis, down-regulates the expression of numerous testis-specific long non-coding RNAs.

This paper investigates the role of Topaz1 in murine spermatogenesis, showing it stabilizes testis-specific long non-coding RNAs and is critical for terminal differentiation but not essential for fertility.