Molecular BiologyScientific ReportsPeer-reviewed
Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility
Jurij Froese, Marco Mandalari, Monica Civera…·Kay Grobe
This study shows that Omicron SARS-CoV-2 spike proteins balance heparan sulfate interaction stability and dynamics to enhance mobility in the extracellular matrix, which can be targeted pharmacologically.