Author

Antonella Bisio

Istituto di Ricerche Chimiche e Biochimiche G. RonzoniORCID 0000-0002-6686-5504Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

Edwin Alexander YatesiD· 2 shared A. Turner· 1 shared Courtney J. Mycroft‐WestiD· 1 shared Cristina GardiniiD· 1 shared Daniele Di IorioiD· 1 shared Dominik LenhartiD· 1 shared Elena UrsoiD· 1 shared Elisa VicenziiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMolecular Biology

Edwin Alexander YatesORCID

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2 papers

Recent·Most cited

Evolution of SARS-CoV-2 spike trimers towards optimized heparan sulfate cross-linking and inter-chain mobility

Jurij Froese, Marco Mandalari, Monica Civera, Stefano Elli, Isabel Pagani, Elisa Vicenzi, Itzel Garcia‐Monge, Daniele Di Iorio, Saskia Frank, Antonella Bisio, Dominik Lenhart, Rudolf Gruber, Edwin Alexander Yates, Ralf P. Richter, Marco Guerrini, , Kay Grobe

This study shows that Omicron SARS-CoV-2 spike proteins balance heparan sulfate interaction stability and dynamics to enhance mobility in the extracellular matrix, which can be targeted pharmacologically.

Scientific Reports · Dec 31, 2024Peer-reviewedMolecular Biology

Enzymatic access to the rare ΔUA (1->4) Glc 3, 6, N-sulfated heparin disaccharide, implications for heparin quality control

Taran Kaur Kandola, Courtney J. Mycroft‐West, Marcelo Andrade de Lima, A. Turner, Cristina Gardini, Elena Urso, Gavin John Miller, Antonella Bisio, Edwin Alexander Yates, Marco Guerrini, L. Wu, Mark Andrew Skidmore

This study characterizes a Bacteroides eggerthii lyase that efficiently cleaves heparin to release a rare anticoagulant disaccharide, offering improved methods for quality control.

bioRxiv · Sep 26, 2024 · PreprintBiochemistry