Tuo Zhang

This study identifies the role of dorsal raphe nucleus neurons in stress-induced shifts from goal-directed to habit-driven behavior using mouse models and molecular profiling.

The paper develops vascularized macrophage-islet organoids to study immune-mediated β cell pyroptosis during viral infection and identifies TNFSF12-TNFRSF12A as a key mechanism.

This study identifies transcriptomic changes in mouse ischemic cerebral microvessels and finds shared alterations with human stroke data, highlighting pathways relevant for preclinical research.

EthSEQ annotates ethnicity from whole exome sequencing data with high precision, validated on 1,000 Genome Project and TCGA datasets.

This study reports that 17% of advanced cancer patients have clinically relevant germline variants, with higher rates of cancer-associated variants compared to control cohorts.