Bioinspired Oxidized mRNA Lipid Nanoparticles for Ex Vivo Engineering of Chimeric Antigen Receptor Macrophages Targeting Solid Tumors
Alvin J. Mukalel, Tina Tylek, Hannah C. Geisler, Erin M. O’Brien, C. Pritchett Frazee, Jacqueline J. Li, Ajay S. Thatte, Hannah C. Safford, Christian G. Figueroa‐Espada, Mohamad‐Gabriel Alameh, Alex G. Hamilton, David Mai, Neil C. Sheppard, Carl H. June, Drew Weissman, , Michael J. Mitchell
This paper develops a bioinspired oxidized lipid nanoparticle platform for mRNA-based engineering of CAR-Ms to target solid tumors, showing improved delivery and tumor-killing efficacy.
Bioengineering & Translational Medicine · Mar 30, 2026Peer-reviewedBioengineering