Omar O. Abudayyeh

flashscenic accelerates single-cell GRN analysis using GPU acceleration, improving speed and enabling benchmarking of integration strategies in AML data.

This paper develops strategies to redirect lipid nanoparticle targeting away from the liver and toward specific tissues using engineered proteins and antibody conjugation.

The paper introduces T-PGI, a system for scarless, programmable genome integration, showing high-fidelity insertion with minimal structural variants.

This paper introduces EVOLVEpro, a few-shot learning framework using protein language models to rapidly improve protein activity with minimal experimental data.

This paper introduces PRECISE, a method for programmable RNA editing that enables precise insertion, substitution, and deletion of RNA sequences in pre-mRNAs, with high efficiency and fidelity.

The paper identifies widespread RNA-guided nucleases in eukaryotes and their viruses, showing they can be used for genome editing in human cells.

This study characterizes the RNA-guided nuclease-protease complex Cas7-11-Csx29, showing target RNA binding activates Csx29 to cleave Csx30, leading to cell death.

This paper introduces RADARS, a programmable RNA-sensing technology that uses ADAR-mediated RNA editing to control protein expression based on target RNA transcripts in mammalian cells, with applications in gene therapy and synthetic biology.

The paper tests 16 Cpf1 orthologs for genome editing activity in eukaryotic cells, identifying four active enzymes including Mb3Cpf1 with robust indel formation and PAM tolerance.

The paper demonstrates multiplex gene editing in mammalian cells and mouse brains using a single CRISPR array processed by Cpf1 without requiring additional factors.