Cynthia J. Siebrand

The paper compares SNIPR, synNotch, and TRUCK systems for Aβ-targeting cell-based drug delivery in Alzheimer's disease, finding SNIPR and synNotch outperform TRUCK in therapeutic response.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

This paper demonstrates that a synNotch receptor can target extracellular Aβ aggregates, enabling the production of AD therapies like Lecanemab and Aducanumab in response to these aggregates.

The paper evaluates senolytic therapies in a human neuron AD model, finding Navitoclax's neurotoxicity and NK92's preferential targeting of senescent-like cells.

The paper demonstrates that CARs based on AD antibodies can detect and discriminate between tau and distinct Aβ species, suggesting their potential for targeted AD therapies.

This study identifies age-related lipidomic changes in neural stem cells using mass spectrometry and shows that lipid modifications affect NSC function and activation.