Aeowynn J. Coakley

Expression of tardigrade intrinsically disordered proteins in C. elegans reveals variable effects on aging and stress

Constitutive somatic expression of four tardigrade disordered proteins shortened C. elegans lifespan and healthspan and gave little stress protection. Three of the four reduced polyQ aggregation under hyperosmotic stress.

Form and function of actin impacts actin health and aging.

This study investigates how actin structure and function affect aging in C. elegans and finds that actin dysfunction accelerates aging hallmarks and correlates with human age-related decline in gait speed.

The aging mouse lipidome

This study maps age- and sex-related lipid changes across 10 mouse organs, revealing organ-specific and sex-dependent patterns in the lipidome during aging.

A metabolic atlas of mouse aging

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

Distinct mechanisms of non-autonomous UPRER mediated by GABAergic, glutamatergic, and octopaminergic neurons.

The paper identifies distinct roles of GABAergic, glutamatergic, and octopaminergic neurons in mediating non-autonomous UPRER through transcriptomic and functional analyses in C. elegans.

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

The fidelity of transcription in human cells

The paper estimates transcription fidelity in human cells, identifies factors controlling its accuracy, and links transcription errors to Alzheimer's disease progression.