Mark N. Wass

This study characterizes phenotypic plasticity in EGFR inhibitor-resistant NSCLC cell lines, showing diverse resistance mechanisms and metabolic adaptations across sublines.

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

The paper identifies coevolving variant pairs in individual human genomes using structural data, finding over 4,000 variant-variant interactions and supporting their coevolutionary nature.

The paper reports results from the CAFA3 challenge, showing improved computational protein function prediction and new annotations for over 1000 genes through experimental screens in C. albicans, P. aureginosa, and Drosophila.

The paper identifies 22 likely transporter proteins in a minimal bacterial genome, highlighting their role in nutrient uptake and waste disposal despite many metabolic enzymes being removed.

The paper investigates the evolution of myosin II isoforms in mammals, finding that three isoforms show sequence divergence correlated with increasing body mass.