Yu Chen

This study identifies HexBMP(22:6_22:6) as a novel biomarker for mutant GBA1 using lysosomal profiling in mice and human samples.

The paper compares dopaminergic neurons from siblings with Gaucher disease to investigate genetic factors contributing to Parkinsonism.

The paper investigates how GBA1 mutations affect glycoprotein nonmetastatic melanoma protein B (GPNMB) expression in dopaminergic neurons, linking lipid accumulation to Parkinson's disease risk.

The paper investigates the biological impact of GBA1 mutations using multi-omics in isogenic iPSC lines, finding limited overlapping results across cell types and suggesting RNA-based quantitation may not be optimal for characterizing GCase mechanisms.

This paper develops high-throughput assays to identify and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase, showing NCGC326 reverses pathological accumulation and synergizes with proteostasis regulators.

This study characterizes two novel human GCase antibodies for use in various assays to advance Parkinson disease research.