Author

Darian Williams

National Institutes of HealthORCID 0000-0002-4572-3056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ellen SidranskyiD· 2 shared Mark J. HendersoniD· 2 shared Yu CheniD· 2 shared Abhijeet KapooriD· 1 shared Alexandra GehrleiniD· 1 shared Andrew N. HoganiD· 1 shared Charis Ma· 1 shared Chase CheniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Ellen SidranskyORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism

Chase Chen, Charis Ma, Richard Sam, Jens Lichtenberg, Tiffany Chen, Ying Hao, Ziyi Li, Isabelle Kowal, Katherine M. Andersh, Yue Andy Qi, Gani Perez, Ellen Hertz, Yan Li, Darian Williams, Mark J. Henderson, , Yu Chen

The paper investigates how GBA1 mutations affect glycoprotein nonmetastatic melanoma protein B (GPNMB) expression in dopaminergic neurons, linking lipid accumulation to Parkinson's disease risk.

bioRxiv · Jun 23, 2025 · PreprintNeuroscience

Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease

Darian Williams, Logan M. Glasstetter, Tiffany T. Jong, Tiffany Chen, Abhijeet Kapoor, Sha Zhu, Yanping Zhu, Raul Calvo, Alexandra Gehrlein, Kimberly Wong, Andrew N. Hogan, David J. Vocadlo, Ravi Jagasia, Juan Marugán, Ellen Sidransky, , Yu Chen

This paper develops high-throughput assays to identify and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase, showing NCGC326 reverses pathological accumulation and synergizes with proteostasis regulators.

Proceedings of the National Academy of Sciences · Oct 10, 2024Peer-reviewedPharmacology & Toxicology