Xiaodi Zhang

This study introduces an ultra-rare AKAP11 protein-truncating variant in mice, showing it causes anxiety- and depression-like behaviors and disrupts PKA signaling.

This paper develops PMO-based RNA-degrading chimeras that target SNCA mRNA to reduce α-synuclein levels and prevent pathological aggregation in vitro and in vivo.

This study develops a spectral flow cytometry approach to identify macrophage subpopulations in healthy and MASH livers, revealing distinct autofluorescence signatures and highlighting the importance of accurate AF correction.

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

The paper examines variations in large-scale spatiotemporal brain activity patterns across different brain states using resting-state fMRI data from humans and rats.

The paper examines the relationship between BOLD and neural activity using simultaneous rs-fMRI and LFP recordings in rats, finding that high-amplitude LFP events drive BOLD signals and co-activation patterns.

The paper maps whole-brain dynamics into a continuous state space using scale transformations and identifies stimulus-dependent brain states from resting and task data.