Kundlik Gadhave

Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras

This paper develops PMO-based RNA-degrading chimeras that target SNCA mRNA to reduce α-synuclein levels and prevent pathological aggregation in vitro and in vivo.

Neuronal LAG3 facilitates pathogenic α-synuclein neuron-to-neuron propagation

This study shows neuronal LAG3 is essential for α-synuclein propagation and neurodegeneration in Parkinson's disease, suggesting LAG3 as a therapeutic target.

α-Synuclein Strain Dynamics Predict Cognitive Transitions in Parkinson's Disease

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

Pathologic α-Synuclein-NOD2 Interaction and RIPK2 Activation Drives Microglia-Induced Neuroinflammation in Parkinson's Disease

This paper identifies NOD2/RIPK2 signaling as a key driver of neuroinflammation in Parkinson's disease, showing that pathological α-synuclein activates this pathway in microglia, leading to neurodegeneration and that targeting NOD2 or RIPK2 protects dopamine neurons.

Pathological Tau transmission initiated by binding lymphocyte-activation gene 3

This study identifies Lag3 as a neuronal receptor for Tau preformed fibrils, essential for their uptake, propagation, and transmission in Tauopathies.

When Darkness Becomes a Ray of Light in the Dark Times: Understanding the COVID-19 via the Comparative Analysis of the Dark Proteomes of SARS-CoV-2, Human SARS and Bat SARS-Like Coronaviruses

This study compares the structural order and disorder in the proteomes of SARS-CoV-2, human SARS, and bat SARS-like coronaviruses to identify functional features relevant to viral biology and drug discovery.