Anne Osbourn

The paper predicts and validates amino acid residues determining product specificity in plant oxidosqualene cyclases using structural and computational methods.

This study identifies two pathogen-induced diterpenoid pathways in wheat that produce antimicrobial compounds, revealing organizational separation of diterpenoid-based chemical defenses.

plantiSMASH 2.0 improves detection, annotation, and prioritization of plant biosynthetic gene clusters by expanding BGC types and adding substrate prediction and regulatory analysis.

The paper identifies a biosynthetic gene cluster in Rhodococcus fascians that produces lydiamycin A, a novel HPS-containing macrocyclic pentapeptide with antibacterial activity against peptide deformylase.

plantiSMASH identifies and analyzes plant biosynthetic gene clusters using genomic and transcriptomic data to prioritize candidates and study their evolutionary conservation.