Christopher E. Miles

Hierarchy of spindle forces in prometaphase

The paper analyzes 3D trajectories of chromosomes and spindle poles to reconstruct spindle forces in prometaphase, finding that pole-pole segregation is robust and primarily driven by interpolar forces.

Efficient approximate Bayesian inference for large, heterogeneous biological datasets

The paper introduces an adaptive minibatch approach for approximate Bayesian inference, improving speed-precision tradeoffs for large, heterogeneous biological datasets.

Reconstructing Actin Dynamics of the Leading Edge from Observational Data

The paper reconstructs a mechanistic model of actin dynamics at the leading edge of mesenchymal cells using multiplex microscopy data and regression analysis.

The kinetochore corona orchestrates chromosome congression through transient microtubule interactions

This paper uses live-cell microscopy and computational modeling to show that chromosome congression is driven by stochastic, transient microtubule interactions at the kinetochore corona.

Bayesian BiLO: Bilevel Local Operator Learning for Efficient Uncertainty Quantification of Bayesian PDE Inverse Problems with Low-Rank Adaptation

BiLO: Bilevel Local Operator Learning for PDE Inverse Problems

The paper introduces BiLO, a neural network method for solving PDE inverse problems by formulating them as bilevel optimization problems, showing it enforces PDE constraints and handles noisy data effectively.

Scalable Inference and Identifiability of Kinetic Parameters for Transcriptional Bursting from Single Cell Data

This paper develops a computational pipeline to infer kinetic parameters from single-cell RNA sequencing data and assesses parameter identifiability using the stochastic telegraph model.

Incorporating spatial diffusion into models of bursty stochastic transcription

This paper introduces a spatial stochastic model of nuclear mRNA with telegraph transcriptional dynamics and shows it can be approximated by a Poisson-Beta distribution for efficient parameter inference.

Coaching ribosome biogenesis from the nuclear periphery

This study shows that nuclear invaginations regulate ribosome biogenesis by contacting nucleoli, with high curvature increasing ribosome production and low curvature reducing it.