Lukas B. Krone

Cortical layer 6b mediates state-dependent changes in brain activity and effects of orexin on waking and sleep

This study shows that silencing layer 6b neurons in mice alters theta frequency and EEG power during wake and sleep, and reduces orexin-induced wakefulness.

Contrasting effects of global and local cortical activity on the regulation of sleep

This study investigates how global and local cortical activity affects sleep regulation using chemogenetic manipulations of Rbp4-Cre+ neurons.

Deficient synaptic neurotransmission results in a persistent sleep-like cortical activity across vigilance states in mice

This study shows that a mutation in synaptobrevin 2 in mice leads to abnormal cortical activity patterns across sleep and wake states, resembling deep anaesthesia.

Increased slow wave activity in response to sleep deprivation is highest immediately after micro-arousals

The paper investigates how micro-arousals affect neural activity in the motor cortex of sleep-deprived mice, finding increased slow wave activity immediately after micro-arousals.

Somnotate: A probabilistic sleep stage classifier for studying vigilance state transitions

Somnotate is a probabilistic classifier that improves sleep stage annotation in mice by identifying intermediate states and transitions, outperforming human experts.

Oscillatory-Quality of sleep spindles: from properties to function

This study introduces a new metric, oscillatory Quality (o-Quality), to quantify sleep spindle oscillatory strength in mice and links it to functional roles in sleep.

Detection of neuronal OFF periods as low amplitude neural activity segments

The paper identifies low amplitude neural activity segments during NREM sleep as OFF periods, showing they have distinct characteristics and new properties like vigilance-state-dependent duration.

Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice

This study shows that clozapine-N-oxide and compound 21 affect sleep in mice, suggesting that chemogenetic actuators may have off-target effects beyond DREADD receptor activation.

Neuronal-spiking-based closed-loop stimulationduring cortical ON and OFF states in freely moving mice

This paper develops a closed-loop stimulation method using neuronal spiking activity to detect ON and OFF states during slow oscillations in freely moving mice.

A role for the cortex in sleep-wake regulation

This study shows that silencing specific cortical neurons in mice increases wakefulness and reduces sleep rebound after deprivation, highlighting the cortex's role in sleep regulation.