Maxum E. Paul

The paper examines how RASA1 mutations affect RasGAP protein function, identifying distinct mutation classes and highlighting the C2 domain's unique regulatory role.

The paper optimizes conditions for GTP loading of H-Ras by evaluating factors like time, temperature, concentration, and mutations to enhance nucleotide exchange efficiency.

This study shows the C2 domain enhances Ras GTPase activating protein catalytic activity by interacting with the Ras allosteric lobe, as demonstrated through structural analysis and mutation studies in mice and SynGAP.