Di Chen

The C2 domain augments Ras GTPase Activating Protein catalytic activity

This study shows the C2 domain enhances Ras GTPase activating protein catalytic activity by interacting with the Ras allosteric lobe, as demonstrated through structural analysis and mutation studies in mice and SynGAP.

An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves

Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations

The paper identifies genetic variants in RASA1 and EPHB4 associated with vein of Galen malformations through exome analysis and single-cell transcriptomics.

RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice

This study shows that RASA1 is required for the development of lymphovenous and venous valves by regulating collagen IV export from endothelial cells in mice.