The C2 domain augments Ras GTPase Activating Protein catalytic activity
Maxum E. Paul, Di Chen, Kimberly J. Vish, Nathaniel L. Lartey, Elizabeth Hughes, Zachary T. Freeman, Thomas L. Saunders, Amy L. Stiegler, Philip D. King, Titus J. Boggon
This study shows the C2 domain enhances Ras GTPase activating protein catalytic activity by interacting with the Ras allosteric lobe, as demonstrated through structural analysis and mutation studies in mice and SynGAP.
Proceedings of the National Academy of Sciences · Feb 3, 2025Peer-reviewedBiochemistry