Amalia Perna

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

This study compares T-cell signatures and astroglial reactivity in Parkinson's disease across animal models with different regenerative capacities, finding species- and model-specific immune profiles.

This study uses single-cell immunoprofiling to identify distinct immune signatures in Lewy body disease compared to other neurodegenerative and immune conditions.

The paper investigates Notch signaling's role in synaptic dysfunction and Alzheimer's disease by analyzing gene expression in mouse models and human brain tissue, identifying key targets and their expression patterns across disease stages.