René Dreos

Transcriptional Dynamics and Chromatin Accessibility in the Regulation of Shade-Responsive Genes in Arabidopsis

This study investigates how chromatin accessibility and PIF7 binding regulate shade-responsive gene expression in Arabidopsis under short and prolonged shade exposure.

Ribosomal modification by BUD23 drives selective translational control over energy state and metabolic health

This study identifies BUD23 as a regulator of energy homeostasis by controlling translation of mitochondrial and lipogenic mRNAs, linking ribosomal modification to metabolic health.

Pus7 mutation links tRNA dysregulation to aggressive behavior through activation of the integrated stress response and glycolytic reprogramming

The paper shows that Pus7 mutations reduce tRNA-Asp levels, activating the integrated stress response and glycolytic reprogramming, which contributes to aggressive behavior.

Comprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster

This study maps 2'-O-methylation sites and identifies C/D box snoRNAs in Drosophila rRNAs, showing limited stress-induced variation in methylation levels.

A novel Smg6 mouse model reveals regulation of circadian period and daily CRY2 accumulation through the nonsense-mediated mRNA decay pathway

This study uses a Smg6 mouse model to show that NMD pathway downregulation affects circadian period length and daily CRY2 mRNA accumulation.

Analysis of eukaryotic lincRNA sequences reveals signatures of repressed translation in species under strong selection

The paper analyzes lincRNA sequences across six eukaryotes to identify sequence signatures of repressed translation, finding shorter ORFs and suboptimal codon usage in species under strong selection.

Computational identification and experimental characterization of preferred downstream positions in human core promoters

The paper identifies and experimentally validates preferred downstream positions in human core promoters resembling the Drosophila DPE, showing strict spacing dependency on the Inr.

Revealing Notch-dependencies in synaptic targets associated with Alzheimer's disease

The paper investigates Notch signaling's role in synaptic dysfunction and Alzheimer's disease by analyzing gene expression in mouse models and human brain tissue, identifying key targets and their expression patterns across disease stages.

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

This study presents the cryo-EM structure of the mammalian ribosome during SARS-CoV-2 RNA translation, revealing the pseudoknot structure that facilitates ribosomal frameshifting and identifies a compound that inhibits viral replication.

Translation is required for miRNA-dependent decay of endogenous transcripts.

The paper shows that translation is required for miRNA-dependent transcript decay, as non-translated lncRNAs are minimally affected by miRNA loss, while translated transcripts are destabilized.

Human NMD ensues independently of stable ribosome stalling

This study challenges the prevailing model of NMD by showing that ribosome stalling at stop codons does not occur during NMD activation in vitro or in vivo.

Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthrough

This study shows that ABCE1 depletion inhibits NMD by promoting stop codon readthrough, which displaces NMD factors from the 3' UTR.

Opposing chromatin remodelers control transcription initiation frequency and start site selection

The paper investigates how opposing chromatin remodelers influence transcription initiation frequency and start site selection in budding yeast by analyzing their binding and nucleosome displacement activity.