This paper performs a large-scale GWAS meta-analysis of neuropathologic lesions in Alzheimer's disease and related dementias, identifying both known and novel genetic associations.

PLoS Genetics · Jun 29, 2026Peer-reviewedGenetic & Genomic Medicine

Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders

Ajneesh Kumar, Nicholas R. Ray, Jiji Thulaseedhara Kurup, Pamela del Rosario, Masood Manoochehri, Colin M. Stein, Alyssa N. De Vito, Brenna Cholerton, Robert A. Sweet, Philip L. De Jager, Hans‐Ulrich Klein, Michael L. Cuccaro, Gary W. Beecham, Edward D. Huey, Christiane Reitz

Alzheimer s & Dementia · Mar 1, 2026Peer-reviewedGenetic & Genomic Medicine

α-Synuclein Strain Dynamics Predict Cognitive Transitions in Parkinson's Disease

Kundlik Gadhave, Ning Wang, Kyungdo Kim, Enquan Xu, Xiaodi Zhang, Hanyu Li, Jacob Deyell, Jun Yang, Anthony Wang, Youngjae Cha, Ramhari Kumbhar, Haiqing Liu, Lili Niu, Rong Chen, Shu Zhang, , Xiaobo Mao

The paper identifies distinct α-synuclein strains associated with cognitive decline in Parkinson's disease and shows AI-based analysis of these strains improves clinical stratification.

bioRxiv · Oct 22, 2024 · PreprintNeuroscience

Single-Cell Peripheral Immunoprofiling of Lewy Body Disease in a Multi-site Cohort

Thanaphong Phongpreecha, Kavita Mathi, Brenna Cholerton, Eddie J. Fox, Natalia Sigal, Camilo A. Espinosa, S. Momsen Reincke, Philip Chung, Ling-Jen Hwang, Chandresh R. Gajera, Eloïse Berson, Amalia Perna, Feng Xie, Chi-Hung Shu, Debapriya Hazra, , Thomas Jude Montine

This study uses single-cell immunoprofiling to identify distinct immune signatures in Lewy body disease compared to other neurodegenerative and immune conditions.

bioRxiv · Jan 30, 2024 · PreprintNeuroscience

CSF sTREM2 correlates with CSF tau in advancing Parkinson’s disease

Edward N. Wilson, Michelle S. Swarovski, Patricia Linortner, Marian Shahid, Abigail J. Zuckerman, Qian Wang, Divya Channappa, Paras Singh Minhas, Siddhita D. Mhatre, Edward D. Plowey, Joseph F. Quinn, Cyrus P. Zabetian, Lü Tian, Frank M. Longo, Brenna Cholerton, , Katrin I. Andreasson

The paper examines the correlation between CSF sTREM2 and CSF tau levels in Parkinson’s disease and finds that sTREM2 is elevated in PD subgroups with abnormal tau but not Aβ.

bioRxiv · Jun 30, 2019 · PreprintNeuroscience