Kathleen S. Montine

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

This study uses single-cell immunoprofiling to identify distinct immune signatures in Lewy body disease compared to other neurodegenerative and immune conditions.

The paper analyzes single exosomes in CSF from Alzheimer's and Parkinson's patients and controls, finding reduced ApoE+ exosomes in Alzheimer's patients.

This study uses spatial proteomics to analyze human brain tissues and identifies proteopathies and cell interactions in Alzheimer's disease.

The paper identifies proteomic features of resilience to Alzheimer's disease, finding lower soluble Aβ levels and specific protein interactions in brain regions associated with resistance to dementia.

The paper analyzes synaptic molecular changes in Alzheimer's disease and related conditions using mass cytometry and imaging, identifying disease-specific molecular differences.

The paper uses single-cell epigenomic data to identify functional SNPs associated with Alzheimer's and Parkinson's disease, revealing novel gene-disease associations and regulatory mechanisms.

Omni-ATAC improves ATAC-seq by reducing background noise and enabling analysis of frozen tissues, revealing disease-associated DNA element activities in human brain structures.