MicrobiologybioRxivPreprint
A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in Mycobacterium abscessus
DOI 10.1101/2025.10.26.684512
Author
Ria Sorayah
Agency for Science, Technology and ResearchORCID 0000-0001-5594-1658Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2025 · peak 2/yrCo-Author Collaboration Network
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Recent·Most cited
- MicrobiologyBiomedicine & PharmacotherapyPeer-reviewed
The repurposed STAT3 inhibitor pyrimethamine controls mycobacterial infection-induced vascular permeability and mycobacterial burden
Darryl JY Han, Xiangyu Sui, Sakshi Agarwal…·Stefan H. Oehlers
The paper shows pyrimethamine, an FDA-approved drug, reduces vascular permeability and mycobacterial burden in a zebrafish infection model by inhibiting bacterial dihydrofolate reductase and restoring vascular barrier function.
3 citations